›a serious disease which kills many peopleThe plagueworld history›The plague refers to a disease that appeared several times in the 14th century and later and that killed more than one third of the people in Europe and many people in Africa and Asia; Black Death.›A plague is also a large number of insects or animals which cause damage or unpleasant conditions in an area: [C]Trees throughout the Northeast are being attacked by a plague of gypsy moths.