›behavior, a feeling, or an action that is a direct result of something else: My initial reaction was to call off the party.Senator, what is your reaction to the proposal to cut Medicare benefits?›A reaction is also a change that opposes a previous opinion or behavior: His art is a reaction against photographic realism.›biologyA reaction can also be an unpleasant effect on the body resulting from something eaten or taken, such as a drug.›chemistryA chemical reaction is the change that happens when two or more substances are mixed with each other.