› If skin or material wrinkles, or if something wrinkles it, it gets small lines or folds in it: Sunbathing can prematurely age and wrinkle the skin.Making things more or less smooth or straight wrinkle your brow › to make folds appear on your face above your eyes to show that you are surprised or confusedGrimacing and frowning wrinkle (up) your nose › to show that you dislike something or that you disapprove of something by tightening the muscles in your nose so that small lines appear in the skin: She wrinkled up her nose at the strange smell coming from the kitchen. Amy wrinkled her nose in disapproval.Grimacing and frowning