› to do something that involves risk and could fail but that you hope will succeed or make money: gamble on sth He gambled his political future on the success of the project.gamble with sth The President warned Republicans not to gamble with Medicare. Investors gambled that the US interest rate rise would be the last one this year. Large numbers are gambling on the house price boom - a gamble they may regret if prices fall or interest rates rise.
› to risk money, for example in a game or on a horse race: In the 2000s casinos began to spread, providing alternative places to gamble.