Meaning of “substance” in the English Dictionary

"substance" in English

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uk /ˈsʌb.stəns/ us /ˈsʌb.stəns/

substance noun (MATERIAL)

B2 [ C or U ] material with particular physical characteristics:

an organic/chemical substance
What sort of substance could withstand those temperatures?
illegal substance formal

an illegal drug

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(Definition of “substance” from the Cambridge Advanced Learner’s Dictionary & Thesaurus © Cambridge University Press)

"substance" in American English

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us /ˈsʌb·stəns/

substance noun (MATERIAL)

[ C ] a material with particular physical characteristics:

The pesticide contains a substance that is toxic to insects.

substance noun (IMPORTANCE)

[ U ] importance, seriousness, or relationship to real facts:

Surprisingly, these filmmakers opted for substance over style.

(Definition of “substance” from the Cambridge Academic Content Dictionary © Cambridge University Press)

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They have not become aware of the challenges which require us to live together or of our points in common or even of the substance of our differences.
We are often exposed to misleading advertisements claiming that the addition of a vitamin or another substance to a food product protects consumers from cancer or other diseases of ‘civilisation’.
So, the situation being as it is, we say ‘yes’ to a legal framework of this kind, and let us discuss its substance rather than any legal bases.
The second is one of substance.
I am aware, however, that it will be very difficult to make progress in this direction unless we first make progress on the substance.
The precautionary principle, therefore, prescribes that we do not wait to impose a ban on this substance until the final results of the investigation are known.
I am positive that we shall find it easier to agree on what we mean in substance than on the definitions.
Thirdly, the substance of the debate: that needs to be considered in terms of papers, broad dialogues and other ideas of this kind.
The directive' s key element, or rather the most talked-about part of this proposal is, of course, the table which lists per country the permitted annual emission for each substance.
Nevertheless, it is as well to remember that this declaration will certainly be different from the 1992 decision in form and substance.