A1 informal used to say yes or to give someone permission to do something:
"Can you help me?" "Of course."
The Second World War ended, of course, in 1945.
(Definition of “of course” from the Cambridge Advanced Learner’s Dictionary & Thesaurus © Cambridge University Press)
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can't hear yourself think
If you cannot hear yourself think, you cannot give your attention to anything because there is so much noise.